Less Food
Effective GLP-1 therapy can substantially reduce appetite and food intake. That is part of why the therapy works. But less total food also means fewer opportunities to obtain everything the body still needs.
GLP-1 + Healthy Weight Loss
The weight is coming off.
Protect what you want to keep.
GLP-1-based therapies can make eating less dramatically easier. But muscle, protein, micronutrients, skin, strength and long-term health still need attention.
NOVOS helps support the quality of your GLP-1 journey.
Educational content for people using or considering clinician-prescribed GLP-1-based weight-management therapy. NOVOS products are foods and dietary supplements, not medications, and are not intended to increase the effectiveness of GLP-1 therapy.
WEIGHTBODY COMPOSITIONNUTRITIONMUSCLEHEALTHSPAN
A transformation measured in more than pounds.
The Second Half of the Journey
Eating less gets easier.
Getting enough can get harder.
GLP-1s can make eating less easier. They do not automatically solve the nutrition, muscle, skin, fitness or longevity questions that follow.
Protein
Substantial weight loss can include lean tissue as well as fat. Adequate protein becomes especially relevant when the goal is to preserve muscle and strength.
Micronutrients
Lower food intake can make nutrient density increasingly important. A smaller diet has less room for nutritionally empty calories.
Muscle
Weight loss is not the same thing as fat loss. Resistance training and adequate protein help improve the quality of the weight-loss process.
Gut
Nausea, early fullness, constipation, diarrhea and other gastrointestinal effects can change what and how much someone comfortably eats. Nutrition has to work with tolerance.
Skin + Appearance
Large changes in body weight can also affect skin laxity and facial volume. Lost facial fat and skin quality are related but different issues.
The goal is not simply less weight.
It is better body composition and better health.
Quality of Weight Loss
The scale cannot tell you what you lost.
Body weight is the sum of several compartments. Two people can lose the same number of pounds with very different effects on health and function.
Simulated scale
200
POUNDS
Fat mass38%
The target of healthy weight loss.
Lean mass34%
Includes skeletal muscle, other non-fat tissues and body water.
Water18%
Fluctuates with diet, glycogen and hydration.
Bone + organs10%
Largely stable in healthy adults.
Weight loss can come from several compartments.
Lose excess fat.
Preserve as much muscle, strength and function as practical.
Conceptual illustration. Not individual clinical data.
Lean mass is not synonymous with skeletal muscle. It includes multiple non-fat tissues and body water: organs, connective tissue, bone and the water held within them, alongside muscle.
When a study reports lean-mass change during weight loss, only part of that change reflects skeletal muscle. This is why sensational claims like a fixed percentage of weight lost being muscle are misleading.
25%
to 39%
Some lean tissue loss accompanies major weight loss.
In a 2026 meta-analysis of randomized incretin trials, lean mass represented roughly 25% to 39% of total weight lost depending on therapy.
IMPORTANT
Lean mass is not the same as skeletal muscle.
Resistance-training lifestyle interventions in the analysis showed a more favorable lean-mass profile.
- What was studied?
- A 2026 meta-analysis pooling randomized controlled trials of incretin-based therapies (GLP-1 and dual-agonist medications) reporting body-composition outcomes.
- What was measured?
- Changes in fat mass and lean mass across treatment arms, and the share of total weight lost attributable to lean mass.
- What did it find?
- Lean mass accounted for roughly 25% to 39% of total weight lost, varying by therapy. Trials and interventions incorporating resistance training showed a more favorable lean-mass profile.
- What does it not prove?
- It does not show that the lean tissue lost was skeletal muscle specifically, does not predict any individual's outcome, and does not establish that any supplement prevents lean-mass loss.
Protect the tissue you worked years to build.
Muscle preservation during weight loss is a system, not a pill. Exercise remains foundational.
1
Train
Resistance training
The signal.
2
Eat
Adequate protein
The building material.
3
Recover
Nutrition + recovery
The environment.
Where NOVOS fits
PRIMARY
NOVOS Bar
Primary nutritional layer.
NOVOS Core
Supporting recovery and muscle-function systems.
NOVOS Boost
Optional cellular-energy layer.
No NOVOS product has been shown to prevent lean-mass loss during GLP-1 therapy. Resistance training, adequate total protein and individualized medical guidance remain the relevant strategy.
Make It Personal
What becomes harder when you eat less?
Choose a goal to see why it matters and where NOVOS fits, honestly.
Why it matters
Protein supports muscle-building nutrition during weight loss.
Best NOVOS fit
NOVOS Bar
Important limit
One Bar does not represent an individual's entire daily protein requirement.
The NOVOS GLP-1 System
Different products. Different jobs.
Not every product is equally relevant to this journey. Bar leads. Core, Vital and Boost play defined supporting roles.
MOST RELEVANT DURING ACTIVE WEIGHT LOSS
NOVOS Bar
Nutrition when every bite counts.
- 15 g complete plant protein
- 6 to 7 g fiber
- 21 essential vitamins and minerals at 50% DV
- Real-food ingredients
- Five built-in longevity ingredients
ESTABLISHED NUTRITION + INGREDIENT RESEARCH
Bar is the most directly relevant NOVOS product during active GLP-1 weight loss because it helps make a smaller eating occasion more nutritionally useful.
The Primary GLP-1 Nutrition Product
When appetite shrinks, make each eating occasion count.
The GLP-1 challenge Bar addresses is not medication efficacy. It is nutrition. When someone is eating substantially less, a compact source of complete protein, fiber and micronutrients can become especially useful.
15 g
Complete protein
6 to 7 g
Fiber
21
Essential vitamins + minerals
50%
Daily Value of those nutrients
Nutrition values reflect the current NOVOS Bar formulation. See the product page for the live nutrition panel.
Start with protein.
RESISTANCE TRAININGCOMPLETE PROTEINMUSCLE REMODELING
Resistance training provides the adaptation signal. Protein supplies amino acids used to rebuild muscle tissue. NOVOS Bar provides complete plant protein containing all nine essential amino acids.
Bar supports the nutrition.
Training provides the signal.
Major weight loss can include both fat and lean tissue. Protein supplies the amino acids muscle uses for maintenance and remodeling, while resistance training provides the adaptive stimulus that tells the body to keep that tissue.
When total food intake drops substantially, reaching adequate protein from ordinary meals can become harder. Compact, protein-dense foods can help close the gap as part of an overall diet.
One Bar contributes protein toward, but does not cover, an entire daily requirement. Individual needs vary with body size, age and activity; speak with the clinician managing your medication or a registered dietitian for personal targets.
B vitaminsVitamin DVitamin CZincSeleniumIronMagnesiumVitamin AVitamin EFolateIodineChromium
A smaller diet has less room for empty calories.
Eating less means fewer opportunities to obtain vitamins and minerals from food. NOVOS Bar was designed to make one eating occasion more nutritionally complete, with 21 essential vitamins and minerals at 50% Daily Value.
Fewer bites. More nutrition per bite.
No. Deficiency is not inevitable, and actual nutritional requirements and food intake vary widely. The concern is nutritional adequacy when overall intake becomes very low for an extended period.
NOVOS Bar is a nutrient-dense food option, not a treatment for any diagnosed deficiency. If you suspect a deficiency, ask your clinician about appropriate testing and care.
Fiber matters. Tolerance matters too.
NOVOS Bar contributes meaningful dietary fiber. But GI tolerance can vary substantially during GLP-1 therapy. Someone experiencing marked nausea, bloating, vomiting or severe early fullness should not force a high-fiber eating occasion simply to meet a target.
Nutrition has to work with your stomach.
NOVOS Bar is not a treatment for constipation. Bowel habits during GLP-1 therapy are influenced by hydration, overall food pattern, the medication itself and individual tolerance.
Practical basics include fluids, movement and gradually adjusting fiber to comfort. Persistent or significant symptoms should be discussed with the clinician managing your medication.
Complete nutrition should still look like food.
NOVOS Bar combines complete protein, fiber and micronutrients with real-food ingredients: organic olive oil, seed butters, honey, vegetables, cranberry and cocoa.
Functional ingredients are the bonus. Nutrition is the foundation.
- Taurine
- Astaxanthin
- Lion's Mane
- Reishi
- Cordyceps
Built into every Bar. Value-adds on top of the nutrition, not the reason Bar matters here.
Flexibility, Not Rules
One Bar or two?
15 g
protein
6 to 7 g
fiber
21
vitamins + minerals
A nutrient-dense snack or smaller eating occasion when appetite is limited.
Do not force a predetermined portion.
Appetite and GI tolerance vary substantially. The amount someone eats should fit their individual needs, tolerance and healthcare guidance.
Visible Changes
Weight loss can change your face faster than skin can adapt.
Substantial weight loss can reduce facial fat volume and increase visible laxity. The popular phrase "Ozempic face" is not a diagnosis.
A supplement cannot replace lost facial volume.
No NOVOS product has been shown to prevent or restore lost facial fat volume.
How NOVOS fits skin
Primary skin support
NOVOS Core
- Hyaluronic acid
- Glycine
- Vitamin C
- Glucosamine
Preliminary finished-formula skin-firmness research: 22% average improvement, n=4, 6-month pilot.
Preliminary. This does not demonstrate prevention or treatment of GLP-1-related skin laxity or facial volume loss.
Nutritional foundation
NOVOS Bar
- Complete protein
- Micronutrients
- Astaxanthin
Nutrition supports the raw materials skin relies on.
Bar does not prevent loose skin.
Environmental / carotenoid support
NOVOS Vital
- Lutein + zeaxanthin
- Skin oxidative-stress support
- Environmental resilience research
Daily-system support under the current Vital formulation and brand guidelines.
Vital does not prevent facial fat loss.
The Healthspan Layer
The weight is coming off.
What else do you want to improve?
GLP-1 therapy can be a powerful health inflection point. Core's role is not to increase weight loss. Its role is to help broaden the goal from less weight to better healthspan.
WEIGHTSTRENGTHFITNESSCARDIOVASCULAR HEALTHRECOVERYSKINLONGEVITY
Don't stop at the scale.
GLP-1-based therapies themselves can provide meaningful cardiometabolic benefits in appropriate populations. Core is not a correction for anything the medication fails to do.
In separate research unrelated to GLP-1 treatment, the complete NOVOS Core formulation has been studied in randomized, double-blind, placebo-controlled human research.
Endothelial functionArterial flexibilityHealthy blood pressure already within the normal range
SEPARATE NOVOS CORE HUMAN RESEARCH
This trial was not conducted in GLP-1 users and did not study weight loss or obesity treatment.
- What was studied?
- The complete, finished NOVOS Core formulation in a randomized, double-blind, placebo-controlled human trial.
- What was measured?
- Cardiovascular-aging physiology, including measures of endothelial function and arterial flexibility.
- What does it not prove?
- It was not performed in GLP-1 users, did not study weight loss, and does not establish that Core prevents cardiovascular disease or interacts with GLP-1 therapy.
You're already changing your body. Use the momentum.
- Build strength
- Improve fitness
- Eat better
- Support cardiovascular health
- Think in decades
The scale can be the catalyst.
It should not be the finish line.
Targeted Daily System Support
Your gut is part of the journey too.
Vital is a Daily System Support gummy: daily support against oxidative and environmental stress, with targeted support for your eyes, skin, gut and brain.
Chicory Root Inulin
4 g chicory root for prebiotic support.
At the relevant serving structure, chicory-root inulin feeds bifidobacteria, the beneficial bacterial population shown to respond to inulin.
Prebiotic support is not GLP-1 side-effect treatment.
Vital is not intended to treat constipation, nausea, delayed gastric emptying, bloating or other medication adverse effects, and it does not increase weight loss.
Weight loss isn't the only thing happening in your life.
Vital's broader role is daily support for systems exposed to everyday stress.
Eyes
Lutein + zeaxanthin support the eye's protective pigment, with ingredient research on eye strain and fatigue.
Skin
Carotenoid support for skin exposed to everyday oxidative and environmental stress.
Brain
Ingredient research on memory and learning under the current Vital formulation guidelines.
These are general daily-system benefits, not consequences of GLP-1 treatment.
Sometimes the limiting factor is your stomach.
Nausea, early satiety, constipation, diarrhea, vomiting and bloating can all change what and how much someone comfortably eats during GLP-1 therapy.
NOVOS products are not treatments for these side effects.
Prioritize small, nutrient-dense, easy-to-tolerate foods and fluids. Cold or neutral foods are often easier than large hot meals. Eat to comfort, not to a fixed quota.
Increase fiber gradually and only to tolerance. During periods of marked nausea or bloating, it is reasonable to favor gentler foods rather than forcing fiber targets.
Persistent vomiting, inability to hydrate, severe or persistent abdominal pain, or inability to maintain adequate nutrition warrants prompt medical guidance. Speak with the clinician managing your medication before making any medication changes.
The Journey
Where are you in the journey?
Priorities shift as therapy progresses. Select a phase to see what matters most and where NOVOS fits.
Priorities
- 1Protein
- 2Resistance training
- 3Micronutrient density
- 4Muscle preservation
- 5Food quality
Where NOVOS fits
Match NOVOS to what you're trying to protect.
An honest matrix of where each product is strong, and where it is not.
What matters most?
BEST FIT
NOVOS Bar
15 g complete plant protein in a compact eating occasion.
Important limit: One Bar is not a full day's protein target.
Explore NOVOS BarWhat customers say.
"The taste is genuinely good and it holds me over. It has become my go-to when I do not feel like a full meal."
Karen M.Verified Customer · NOVOS Bar"Convenient, real ingredients, and it does not taste like a protein bar. I keep them in my bag and in the office."
David R.Verified Customer · NOVOS Bar"Simple to take every morning and I appreciate that the formula is backed by actual published work."
Susan L.Verified Customer · NOVOS CoreIndividual experiences vary and are not clinical evidence.
Guided by longevity scientists.
Dr. George Church
Professor of Genetics, Harvard Medical School
Dr. Pamela Maher
Research Professor, Salk Institute for Biological Studies
Dr. Diogo Barardo
Director of Research, NOVOS
Titles and affiliations reflect the NOVOS Scientists page. Advisory involvement does not constitute an endorsement of any GLP-1-related claim.
If you're on a GLP-1, start with the problem in front of you.
Most people actively losing weight
Start with Bar.
Protein, fiber, micronutrient density and real-food nutrition when eating opportunities are smaller.
Explore NOVOS BarReady to turn weight loss into a longevity project
Add Core.
Broader healthy-aging support with human cardiovascular research and additional skin and recovery ingredients.
Explore NOVOS CoreGut + daily system support is a priority
Consider Vital.
Targeted chicory-root prebiotic support plus eye, skin and brain daily-system support.
Explore NOVOS VitalFocused NAD+ is already a personal priority
Boost is optional.
Focused NMN and NAD+ support.
Explore NOVOS BoostNot sure?
Answer a few questions and get a recommendation based on your goals and where you are in the journey.
Product FinderQuestions people actually ask.
NOVOS Bar is the most directly relevant product for many people actively losing weight because it provides complete protein, fiber, broad micronutrient nutrition and real-food ingredients in a compact eating occasion. It does not make the medication work better or cause additional weight loss.
No. Bar provides complete protein, which can help support adequate protein intake. Resistance training, adequate total protein, sufficient nutrition and individualized medical guidance remain the relevant muscle-preservation strategy. The finished Bar has not been clinically shown to prevent GLP-1-related lean-mass loss.
Major weight loss can include both fat and lean tissue. Protein supplies amino acids used by muscle, while resistance training provides the adaptive stimulus.
No. Nutritional requirements and actual food intake vary. The concern is that substantial appetite reduction can reduce opportunities to obtain protein and micronutrients. NOVOS Bar is a nutrient-dense food option, not treatment for deficiency.
Vital provides chicory-root inulin for targeted prebiotic support under the current Vital formulation and brand guidelines. It is not intended to treat constipation, nausea, delayed gastric emptying or other medication adverse effects.
Substantial weight loss can reduce facial fat volume and increase visible laxity. No NOVOS product has been shown to prevent or restore lost facial fat volume. Core, Bar and Vital can support different aspects of skin quality and nutrition, but this is different from restoring facial volume.
Core is relevant to the broader health goal rather than medication efficacy. The complete formula has separate randomized human research involving cardiovascular-aging physiology, and Core is designed as the broader NOVOS longevity foundation. The study was not performed in GLP-1 users.
Not established. Boost supplies NMN for focused NAD+ support. It has not been shown to increase GLP-1-driven weight loss.
Do not force food or supplements simply to follow a generic nutrition plan. Persistent vomiting, inability to maintain hydration, severe or persistent abdominal pain, or inability to maintain adequate nutrition should be discussed promptly with the clinician managing the medication.
No NOVOS product has been shown to prevent weight regain after stopping GLP-1 therapy. Long-term management can involve nutrition, resistance training, physical activity, sleep, sustainable habits and continued medical care. Medication decisions belong with the prescribing clinician.
The weight is coming off.
Keep the muscle.
Keep the nutrition.
Build the strength.
Support the rest of your health.
Take the win.
Build on it.
Start with Nutrition
When every eating opportunity counts, build more into it.
- 15 g complete protein
- 6 to 7 g fiber
- 21 essential vitamins and minerals at 50% DV
- Real-food ingredients