Skin that ages slower starts inside.
Feel confident now. Age better over time.
Most skincare is short-term. NOVOS Core supports the biological systems behind how your skin and face age — so you get visible firmness now and slower aging over time.
In a preliminary human study, NOVOS Core users experienced an average 22% improvement in skin firmness after 6 months.
Pilot study, n=4. Range 12%–40%. Individual results may vary.
Over 10 million doses served · Recommended by 1,800+ Doctors & Clinicians
5X AWARDS IN SKINCARE & BEAUTY
Recommended by 1,800+ Doctors & Clinicians. 10 million doses served. 50,000+ members worldwide.
Mayo Clinic Store, Erewhon, Equinox, The Four Seasons, and Sunlife Organics are trademarks of their respective owners.
*Claims are based on randomized, placebo-controlled human clinical research on the finished NOVOS Core Clinical formulation, along with mechanistic and preclinical studies. In vitro and animal studies are not indicative of impact on humans.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Firmer skin starts underneath
Creams sit on top,
but firm skin is built below.
Collagen and elastin live in the deeper layers of your skin, out of reach of topicals. NOVOS Core supports them from the inside.
Skip the complicated beauty supplement routine. One clinically dosed drink.
No more juggling capsules, powders, and serums. One great-tasting daily drink with 12 ingredients at clinically relevant doses to support your skin from within.
Created by Harvard & MIT scientists.
Backed by 7+ years of R&D and a completed randomized, placebo-controlled human clinical trial on the finished formulation.
Firmer skin, clinically studied, from $2.63/day
average improvement in skin firmness after 6 months
Pilot study, n=4. Range 12%–40%. Individual results may vary.
Secure checkout · Ships in 24–48h · Free shipping
What people notice
Firmer, healthier-looking skin
Improved skin hydration and plumpness
A more youthful, rested appearance
Greater skin resilience over time
Visible improvements others notice
The only multi-ingredient longevity formula with randomized clinical trial evidence on the finished product.
Most longevity supplements cite studies on individual ingredients. NOVOS Core is the only multi-ingredient formula tested as a complete product in a randomized, double-blind, placebo-controlled human trial.
Randomized controlled trial
Gold-standard design
Finished formula
Not just ingredients
Human data
Firmness & vascular
Average rating
3,000+ verified reviews
Notice a difference
Reported by customers
Would recommend
To a friend or family member
Doctors recommend
Across the U.S.
This isn't another skincare product
Topical treatments work on the surface. Collagen feeds one pathway. NOVOS Core supports the biology before it shows.
Topical skincare & treatments
Works on the surface
- Targets visible signs at the surface
- Requires ongoing application or visits
- Doesn't address underlying skin biology
- Limited reach beyond the outer skin layers
Collagen supplements
One structural input
- Supplies one structural protein
- Targets a single pathway
- Doesn't support cellular renewal or circulation
- Limited impact on broader skin aging
NOVOS Core
Multi-pathway skin + aging biology
- Supports multiple biological pathways of skin aging
- Multi-ingredient, clinically studied formula
- Supports firmness, hydration, and cellular renewal
- 22% average improvement in skin firmness at 6 months
Pilot study, n=4. Range 12%–40%. Individual results may vary.
Topical treatments work on what's already visible. NOVOS Core supports the biology behind how your skin ages.
- ✓ 30 servings per box
- ✓ Cancel or pause anytime
- ✓ Third-party tested for purity
- ✓ Sugar-free · Vegan · Non-GMO
Support Your Skin From Within
In a preliminary human study, NOVOS Core users experienced an average 22% improvement in skin firmness after 6 months.Pilot study, n=4. Range 12%–40%. Individual results may vary.
Choose from 3 tasty flavors
Choose Your Plan
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Real people. Real visible changes.
Experiences vary, but many customers report healthier-looking skin, more compliments, and a more youthful appearance.
My skin looks great
"The first thing I've noticed is my skin looks firmer and healthier, without even using creams! Will definitely continue using."
Chris H.Verified Customer
Glowing skin
"Great product! I have been using it for nearly a year and have started to notice that my skin looks softer and smoother."
Nasifeh A.Verified Customer
Immediate skin benefits noticed
"Literally days after I started taking your product, I noticed the benefits in my skin."
Maria K.Verified Customer
Compliments on my skin
"I am now 75 years old, and numerous people have commented that I appear much younger and praise the quality of my skin."
Leonard M.Verified Customer
Surprising benefits
"I have seen improvement in the appearance of my skin and have felt more energy. I just feel better day to day, and that's what keeps me coming back."
Tucker D.Verified Customer
Two month review
"I have been taking Core for two months. I feel a lot better. My skin is improving, and I have noticed my hair growing faster and thicker."
Sheri L.Verified Customer
My skin looks great
"The first thing I've noticed is my skin looks firmer and healthier, without even using creams! Will definitely continue using."
Chris H.Verified Customer
Glowing skin
"Great product! I have been using it for nearly a year and have started to notice that my skin looks softer and smoother."
Nasifeh A.Verified Customer
Immediate skin benefits noticed
"Literally days after I started taking your product, I noticed the benefits in my skin."
Maria K.Verified Customer
Compliments on my skin
"I am now 75 years old, and numerous people have commented that I appear much younger and praise the quality of my skin."
Leonard M.Verified Customer
Surprising benefits
"I have seen improvement in the appearance of my skin and have felt more energy. I just feel better day to day, and that's what keeps me coming back."
Tucker D.Verified Customer
Two month review
"I have been taking Core for two months. I feel a lot better. My skin is improving, and I have noticed my hair growing faster and thicker."
Sheri L.Verified Customer
Customer experiences are anecdotal. Individual results vary.
Why people trust NOVOS Core
1,800+ Doctors
Recommended by physicians and clinicians who understand the science of skin aging.
Clinically Studied
Tested in a randomized, placebo-controlled study in healthy adults with preliminary skin firmness data.
Trusted By The World's Best
Found at Mayo Clinic Store, Bumrungrad International Hospital, Erewhon, and Four Seasons.
Science-Driven
Multi-pathway formula designed by longevity scientists to support skin health from within.
Supporting how your body ages, at multiple levels
NOVOS Core includes ingredients associated with biological processes involved in aging, structure, and recovery.
Calcium Alpha-Ketoglutarate
1100mg
How it Helps:
- Supports collagen synthesis
- Promotes skin elasticity & firmness
- Studied for cellular protection, metabolic health, and epigenetic support
Glycine
2000mg
How it Helps:
- Improves collagen synthesis
- Improves skin firmness & strength
Glucosamine Sulfate
1000mg
How it Helps:
- Improves skin hydration
- Improves skin appearance
- Studied for healthy inflammatory balance and calorie-restriction-like metabolic pathways
Hyaluronic Acid
100mg
How it Helps:
- Helps reduce size of wrinkles
- Improves skin suppleness
- Increases skin radiance
Vitamin C
100mg
How it Helps:
- Helps to maintain a proper epigenome
L-Theanine
150mg
How it Helps:
- Helps lower stress and anxiety
- Improves sleep quality
- Helps the body to manage crosslinks
Calcium Alpha-Ketoglutarate
1100mg
How it Helps:
- Supports collagen synthesis
- Promotes skin elasticity & firmness
- Studied for cellular protection, metabolic health, and epigenetic support
Glycine
2000mg
How it Helps:
- Improves collagen synthesis
- Improves skin firmness & strength
Glucosamine Sulfate
1000mg
How it Helps:
- Improves skin hydration
- Improves skin appearance
- Studied for healthy inflammatory balance and calorie-restriction-like metabolic pathways
Hyaluronic Acid
100mg
How it Helps:
- Helps reduce size of wrinkles
- Improves skin suppleness
- Increases skin radiance
Vitamin C
100mg
How it Helps:
- Helps to maintain a proper epigenome
L-Theanine
150mg
How it Helps:
- Helps lower stress and anxiety
- Improves sleep quality
- Helps the body to manage crosslinks
Plus 6 more
6 more longevity ingredients to target the drivers of aging
Rather than targeting a single pathway, NOVOS Core supports multiple systems involved in how the body, and face, age.
Facial aging goes beyond the surface
Skin aging is influenced by more than what you apply topically. These biological processes are associated with how your skin maintains firmness, resilience, and a youthful appearance.
Topical skincare can't reach these systems. NOVOS Core does.
Skin Structure & Extracellular Matrix
The scaffolding of your skin, collagen, elastin, and hyaluronic acid, determines firmness and resilience. Supporting these structures from within is key to maintaining a youthful appearance.
Circulation & Nutrient Delivery
Healthy circulation supports the delivery of oxygen and nutrients to your skin, processes associated with maintaining a healthy glow and supporting skin cell renewal.
Inflammation & Recovery Processes
Chronic low-grade inflammation is associated with accelerated skin aging. Supporting your body's recovery and inflammatory balance may help maintain skin health over time.
Changes in Underlying Tissue
Facial aging involves changes in bone density, fat distribution, and connective tissue beneath the surface, processes that topical products cannot address.
Designed to Meet the Highest Standards
Studied across skin firmness and circulation
NOVOS Core has been evaluated in two separate human studies on the finished formulation: a preliminary pilot study measuring skin firmness, and a randomized, double-blind, placebo-controlled trial measuring vascular markers associated with circulation.
22% average improvement in a preliminary pilot study
In an open-label pilot study (n=4) using an indentometer (a device that measures skin firmness), participants taking NOVOS Core experienced an average improvement of 22% in skin firmness after 6 months.
This reflects measurable changes in how the skin responds to pressure, a key aspect of skin structure and resilience.
Open-label pilot study, n=4. Range 12%–40%. No placebo control. Individual results may vary.
Vascular markers associated with blood flow
In a randomized, double-blind, placebo-controlled trial, NOVOS Core showed statistically significant benefits over placebo on flow-mediated dilation (FMD), a vascular marker associated with blood vessel responsiveness and nutrient delivery.
Statistically significant vs. placebo at measured timepoints.
Healthy circulation plays a role in delivering oxygen and nutrients to tissues, including the skin, supporting overall skin health and vitality.
"It has been a pleasure to watch NOVOS take a disciplined, biology-first approach in a space that too often prioritizes hype over evidence."
Endorsed by Scientists and Physicians Studying Aging at Its Core
NOVOS Core was developed by a team of 7 scientists and physicians from leading institutions including Harvard Medical School, MIT, and other top scientific centers.
Rather than targeting just one pathway, the formulation was designed to support multiple biological processes associated with aging, skin health, and cellular renewal.
"I see NOVOS as inspiring, they approach aging as a complex phenomenon, aiming at all pathways and hallmarks of aging simultaneously."
Dr. George Church, PhD
Harvard Medical School & MIT Professor
"It's the rigorously-researched, science-backed formulations that set NOVOS apart in the longevity supplements space."
Dr. Robert Lufkin, MD
USC School of Medicine Professor
"The study demonstrates that this multi-ingredient formulation exhibits synergistic effects rarely achieved by a nutritional supplement."
Dr. Satomi Miwa
Lecturer for Translational Biology of Aging, Biosciences Institute, Newcastle University
"What really impressed me about NOVOS was the comprehensiveness of their analysis of aging research to design their product."
Dr. Pamela Maher, PhD
Salk Institute & University of British Columbia
"NOVOS has been using a novel science-based approach for developing its formulation. They are a leader in the longevity space."
Dr. J. Pedro Magalhães, PhD
Harvard Medical School
"I see NOVOS as inspiring, they approach aging as a complex phenomenon, aiming at all pathways and hallmarks of aging simultaneously."
Dr. George Church, PhD
Harvard Medical School & MIT Professor
"It's the rigorously-researched, science-backed formulations that set NOVOS apart in the longevity supplements space."
Dr. Robert Lufkin, MD
USC School of Medicine Professor
"The study demonstrates that this multi-ingredient formulation exhibits synergistic effects rarely achieved by a nutritional supplement."
Dr. Satomi Miwa
Lecturer for Translational Biology of Aging, Biosciences Institute, Newcastle University
"What really impressed me about NOVOS was the comprehensiveness of their analysis of aging research to design their product."
Dr. Pamela Maher, PhD
Salk Institute & University of British Columbia
"NOVOS has been using a novel science-based approach for developing its formulation. They are a leader in the longevity space."
Dr. J. Pedro Magalhães, PhD
Harvard Medical School
Why your skin may not reflect how healthy you are
You can do everything right, skincare, diet, sleep, and still notice changes in your skin.
Skin feels less firm over time
Fine lines become more noticeable
Your face looks more tired than you feel
Results from topical products plateau
That's because skin aging is not just a surface issue.
How to Use
Mix one NOVOS Core sachet daily
Add to 6-8 oz of water, juice, or your morning smoothie.
Stir or shake
Dissolves easily. Available in Orange, Tropical Passion, or Unflavored.
Take consistently
Benefits build over time. Clinical results observed at 6 months of daily use.
Feel confident now. Age better over time.
Most products focus on short-term appearance. NOVOS Core is designed to support the biological processes associated with how your body, and your skin, age over time.
NOVOS Core was designed for people who want visible skin support today and a daily formula that also supports the biology of healthy aging over time.
Common questions
Support your skin from within.
Support the biological systems associated with how your skin and face age, for firmer, healthier-looking skin over time.
Drink Your SkincareRecommended by 1,800+ Doctors & Clinicians