How is NOVOS Core different from taking individual longevity ingredients?

NOVOS Core is one formula of 12 ingredients designed around the Hallmarks of Aging, and the complete formula was evaluated in a randomized, double blind, placebo controlled human study.

Has NOVOS Core been studied in humans?

Yes. A randomized, double blind, placebo controlled study at the University of Surrey randomized 61 apparently healthy adults aged 40 and older; 43 completed six months. The primary endpoint was flow-mediated dilation. The manuscript is a preprint and has not yet completed peer review.

Why does finished-formula testing matter?

Published research on combinations of longevity compounds found that 61% performed no better than the strongest single ingredient, and 15% reduced lifespan.

Can NOVOS Core fit into an existing supplement stack?

Every dose is disclosed, so you can review the formula against what you already take. Discuss changes with your healthcare provider, particularly if you take medication.

What does NOVOS Age measure?

Biological Age, Pace of Aging (DunedinPACE), 11 Organ Ages and Telomere Length, from one at-home blood sample.

The NOVOS Longevity System

You and your longevity stack deserve better.

Every supplement in your stack may have strong evidence behind it. The combination should too.

NOVOS Core combines 12 longevity ingredients in one Hallmarks-based formula studied in a randomized, double blind, placebo controlled human trial.

See the Evidence Explore NOVOS Core

NOVOS Core powder pouring from a daily sachet into a glass

What happens when longevity compounds are combined?

61%

of combinations delivered the same or worse result than the best-performing ingredient on its own.

15%

of combinations shortened lifespan.

Based on a series of animal lifespan experiments in which longevity-enhancing compounds were administered in isolation and in combination.

Phelps et al., Aging Cell, 2025

Randomized human clinical trial — NOVOS Core

NOVOS Core improved blood vessel function, arterial flexibility and systolic blood pressure versus placebo.

Randomized
Double blind
Placebo controlled
6 months
Adults 40+

Blood vessel function (FMD)

+2.9 percentage point improvementvs placebo

Flow-mediated dilation (FMD) at six months

Arterial flexibility (PWV)

1.18 m/s improvementvs placebo

Pulse wave velocity (PWV) — lower is better

Systolic blood pressure

6.1 mmHg improvementvs placebo

(for blood pressures already in normal range)

Study independence

Conducted by University of Surrey researchers. Trial pre-registered at ClinicalTrials.gov. Senior author Prof. Christian Heiss retained control over the data and publication decisions.

61 randomized / 43 completed · SSRN preprint · Manuscript under peer review

Explore NOVOS Core Read the preprint

Why should I take it?

A stack clinically studied as a true longevity formula — not a single ingredient with a story attached.

NOVOS Core was studied in a randomized, double-blind, placebo-controlled human trial and shown to support biological systems predictive of lifespan and healthspan. That is the long game. In the short term, people most often notice changes in how they sleep, think, and feel.

Sleep

Support for deeper, more restorative sleep as your routine settles in.

Energy

Steadier day-to-day energy rather than a stimulant spike and crash.

Mood

A calmer, more even baseline reported through the first months of use.

Cognition

Sharper focus and mental clarity across a normal working day.

Skin

Support for firmness and hydration as skin biology is supported from within.

No two people react precisely the same way to nutritional interventions. Individual results will vary with some obtaining no benefit. These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

81% reported feeling a difference.*

Better sleep was one of the most commonly reported benefits.

*Based on a self-reported NOVOS Core customer survey two weeks post-purchase. Individual results may vary.

Put a clinically tested formula at the center of your longevity protocol.

Glycine2,000 mg
Malate (as Magnesium Malate)1,220 mg
Calcium Alpha-Ketoglutarate1,100 mg
GreenGrown® Glucosamine Sulfate (Vegan)1,000 mg
Magnesium (as Magnesium Malate)305 mg
Rhodiola Rosea Root Extract (3% Rosavins, 1% Salidrosides)300 mg
Calcium (as Calcium Alpha-Ketoglutarate)231 mg
L-Theanine150 mg
Vitamin C (as Ascorbic Acid)100 mg
Hyaluronic Acid100 mg
Fisetin100 mg
Organic Ginger Root Extract (2% Gingerols)80 mg
Pterostilbene50 mg
Lithium (as Lithium Aspartate)1 mg

Every ingredient and finished product is tested for purity and contaminants. Every batch is independently verified for quality, purity and potency.

Heavy Metal Tested
Microbiological Screened
Allergen Verified
Shelf-Stability Validated
GMP-Certified Facility
USP-Grade Ingredients

See the Full NOVOS Core Formula →Explore the Research

Your current stack

Put NOVOS Core next to what you already take.

Current stack

A large arrangement of unbranded single-ingredient supplement bottles, jars, powders and capsules

NOVOS Core

Compare the ingredients.

Compare the doses.

Compare the evidence behind the combination.

Approximately 2 to 5 times greater effect in support of healthy endothelial function than the most effective studied supplements (polyphenols, cocoa, and beet root).

No two people react precisely the same way to nutritional interventions. Individual results will vary with some obtaining no benefit.

References: Heiss C. et al., randomized double-blind placebo-controlled NOVOS Core trial (University of Surrey, SSRN preprint, 2025); Heiss C. et al., Flavanols and cardiovascular function, Am J Clin Nutr; Hobbs D.A. et al., Dietary nitrate (beetroot) and vascular function, Br J Nutr.

See the Full NOVOS Core Formula →

The NOVOS System