Recommended by 2,000+ verified clinicians · Available at Mayo Clinic Store, Erewhon & select health retailers
Calm focus · Stress resilience · Healthy aging
Calm under pressure.
Clear when it counts.
NOVOS Core is a once-daily longevity drink formulated with L-Theanine, Rhodiola Rosea, Magnesium and Glycine: ingredients selected for their roles in calm focus, healthy stress response, mental stamina and restorative recovery, within a 12-ingredient system designed to support healthy aging.
No caffeine. No stimulant-style energy spike.
Over 10 million doses served · Recommended by 2,000+ doctors & clinicians
- 150 mg
- L-Theanine
- 300 mg
- Rhodiola Rosea
- 305 mg
- Magnesium · 73% DV
- 2 g
- Glycine
- 12
- Longevity ingredients
- 0
- Caffeine
Finished formula studied in a randomized, double-blind, placebo-controlled human trial.*
*The NOVOS Core clinical trial measured cardiovascular markers. It did not evaluate stress, mood, focus, cognition or sleep. Calm/focus content on this page is based on separate ingredient research and customer-reported experience.
— Award Winning Formulation —
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Developed with scientists and physicians from Harvard, MIT, Salk and other leading institutions.
A daily foundation for high-pressure lives
Not another stimulant.
A different kind of daily support.
NOVOS Core combines ingredients selected for calm attention, stress adaptation, mental stamina and recovery with a broader longevity formulation targeting the biological processes involved in healthy aging.
- Calm Focus
- Healthy Stress Response
- Mental Stamina
- Restful Recovery
- Whole-Body Longevity
One drink pack daily · Free shipping on subscriptions · Pause, skip or cancel anytime
The modern performance problem
You don't always need more stimulation.
You need better regulation.
Stress is a normal biological response. In the right amount, it helps us respond to challenges. But when mental demands remain high, the brain systems responsible for working memory, flexible thinking and executive control can become less effective.1,2
The goal isn't to eliminate stress. It's to stay more resilient when it arrives, and recover when the demand is over.
Calm
Stay composed
Support a healthy response to everyday stress, without positioning the formula as a sedative.
Focus
Stay mentally present
Support the attention and executive processes needed to think clearly when demands are high.
Recover
Be ready again tomorrow
Restorative sleep and overnight recovery help support next-day mental and physical function.
References: Shields GS, et al. Neuroscience & Biobehavioral Reviews. 2016 · Girotti M, et al. Prog Neuropsychopharmacol Biol Psychiatry. 2018. This describes the biology of stress. It is not a claim that NOVOS Core reverses these effects.
Calm shouldn't mean
checked out.
The ideal state isn't sleepy. And it isn't overstimulated. It's calm enough to think clearly, alert enough to perform, and resilient enough to recover.
← Sedated
Flat. Slowed down. Present but not really here.
Calm + Clear
★ Ideal · NOVOS Core
Steady enough to think. Alert enough to perform.
Overstimulated →
Wired, scattered, and paying for it later.
No caffeine
Designed for daily use without adding another source of caffeine to your routine.
Calm attention
L-Theanine · 150 mg
L-Theanine is an amino acid naturally found in tea and one of the best-studied nutritional compounds at the intersection of relaxation and attention.
Stress response
Human randomized research
A randomized, double-blind, placebo-controlled study in healthy adults found that 200 mg/day of L-Theanine for four weeks was associated with improvements in several stress-related and sleep measures.
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Attention
Human randomized research
Randomized studies using approximately 100–200 mg of L-Theanine have reported effects on selected measures of attention and reaction time.
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How it fits Core
Selected to support calm focus without relying on caffeine.
Williams JL et al. Plant Foods Hum Nutr. 2020 · Hidese S et al. Nutrients. 2019;11:2362 · Kahathuduwa CN et al. Nutr Neurosci.
Adaptation
Rhodiola Rosea · 300 mg
Standardized to 3% rosavins + 1% salidrosides
Rhodiola rosea is an adaptogenic botanical with human research examining fatigue, mental performance and function during periods of stress.
Mental performance under stress
Human randomized research
Randomized placebo-controlled trials of standardized Rhodiola extracts have reported improvements in selected measures of mental fatigue or performance during stressful conditions.
Stress-related fatigue
Human randomized research
A randomized placebo-controlled study in people experiencing stress-related fatigue found differences versus placebo in fatigue and selected measures of attention.
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How it fits Core
Included to support stress resilience, stamina and mental performance.
Olsson EMG et al. Planta Med. 2009 · Shevtsov VA et al. Phytomedicine. 2003 · Darbinyan V et al. Phytomedicine. 2000.
Nervous system foundation
Magnesium · 305 mg · 73% DV
as Magnesium Malate · Malate 1,700 mg
Magnesium is required for hundreds of biochemical reactions and plays established roles in normal nerve function, muscle function and cellular energy production.
Established biological roles
Nutrient reference data
Normal nerve function · muscle function · cellular energy production · enzymatic reactions. Core provides 2,000 mg of Magnesium Malate, delivering 305 mg of elemental magnesium (73% of the Daily Value) in one serving.
Transparency note
Why we don't over-claim here
Research on magnesium supplementation and subjective stress is suggestive but mixed, and studies generally have not specifically tested magnesium malate. For that reason, Core's magnesium claim here is foundational nervous-system and energy support rather than an anti-stress treatment claim.
How it fits Core
Included as the foundational mineral behind normal nerve function and cellular energy.
NIH Office of Dietary Supplements, Magnesium Fact Sheet · Boyle NB, Lawton C, Dye L. Nutrients. 2017;9:429.
Recovery
Glycine · 2 g
Glycine is an amino acid that also functions in the nervous system. Small human studies have examined glycine taken before bed for sleep quality, next-day sleepiness and fatigue.
Next-day function
Human research
In sleep-restricted healthy volunteers, 3 g of glycine before bed reduced subjective fatigue and improved selected next-day performance measures.
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How it fits Core
Included as part of Core's broader recovery and healthy-aging formulation.
Bannai M et al. Front Neurol. 2012;3:61. DOI: 10.3389/fneur.2012.00061
Micro-dosed Lithium · 1 mg elemental lithium
A trace mineral studied for long-term brain resilience
Provided as Lithium Aspartate
Lithium occurs naturally in food and water and has been studied for its effects on biological pathways involved in neuronal resilience, neuroplasticity, and healthy brain aging. Population studies of trace environmental lithium exposure and clinical research using higher low-dose lithium have generated intriguing evidence around cognitive aging and brain health.
NOVOS Core provides 1 mg of elemental lithium, a trace nutritional dose far below prescription lithium levels, as part of its multi-pathway approach to supporting long-term brain health.
Research at trace nutritional doses remains emerging. NOVOS Core's 1 mg lithium dose has not been clinically shown to improve mood or cognition or to prevent neurodegenerative disease, and it should not be compared with prescription lithium therapy.
Four ingredients. Different roles.
Not one pathway. A more complete daily foundation.
L-Theanine
Calm attention
150 mg
Rhodiola Rosea
Stress adaptation + stamina
300 mg
Magnesium
Nerve function + cellular energy
300 mg
Glycine
Recovery support
2 g
Centered on calm focus + stress resilience · + 8 additional longevity ingredients
Calm is one benefit. Longevity is the system.
12 ingredients.
One daily longevity drink.
Calm focus, stress resilience and recovery are built into NOVOS Core on purpose, with meaningful doses of L-Theanine, Rhodiola, Magnesium and Glycine. What makes Core different is that those ingredients sit inside a complete longevity formulation, so the same daily drink that helps you stay composed today is also working on the biology of how you age.
Calcium Alpha-Ketoglutarate
1,100 mg
Cellular metabolism
Glycine
2,000 mg
Recovery support
Pterostilbene
50 mg
Cellular signaling
Fisetin
100 mg
Cellular housekeeping
Magnesium Malate
2,000 mg
Nerve function · 305 mg elemental Mg · 73% DV
GreenGrown® Glucosamine Sulfate
1,000 mg
Joint & metabolic support
L-Theanine
150 mg
Calm attention
Rhodiola Rosea Root Extract
300 mg
Stress adaptation · 3% rosavins, 1% salidrosides
Hyaluronic Acid
100 mg
Tissue hydration
Vitamin C (Ascorbic Acid)
100 mg
Antioxidant support · 111% DV
Organic Ginger Root Extract
80 mg
Whole-body support · 2% gingerols
Lithium (as Lithium Aspartate)
1 mg
Trace mineral
The finished formula has been clinically studied
Most supplement formulas cite ingredient studies.
NOVOS Core clinically studied the actual formula.
The complete NOVOS Core formulation was evaluated in a six-month randomized, double-blind, placebo-controlled human clinical trial at the University of Surrey in healthy adults aged 40+.
Endothelial function
+2.9 pp
improvement at six months vs. placebo
Arterial flexibility
1.18 m/s
improvement in pulse wave velocity vs. placebo
Healthy blood pressure
-6.1 mmHg
systolic blood pressure in adults already within the normal range
Head-to-head comparisons
How NOVOS Core compares to leading interventions studied in similar populations
Results compared against published meta-analyses and randomized controlled trials of exercise, diet and supplements in similar populations.
Sustained FMD improvement (%)
Each 1% improvement in FMD has been associated with lower future cardiovascular risk in epidemiological studies.
These improvements were observed in healthy adults already within normal ranges, where further improvements are typically harder to achieve.
Effect sizes are based on published clinical trials and meta-analyses reporting changes in similar biomarkers in adult populations. The NOVOS Core trial measured cardiovascular markers only; it did not evaluate stress, mood, focus, cognition or sleep.
Manuscript under peer review. Trial registration: ClinicalTrials.gov NCT06145087.
What customers say they notice.
81%
of surveyed NOVOS customers reported feeling a difference within two weeks across one or more areas of daily well-being, including energy, sleep, mood, cognition, skin and overall well-being.
Self-reported customer survey. This does not mean 81% experienced a specific calm, mood or focus benefit. Individual experiences vary and are distinct from controlled clinical research.
★★★★★
“I feel more energized and focused throughout the day. It has become part of my morning without me having to think about it.”
★★★★★
“I've noticed increased mental clarity since starting NOVOS Core.”
★★★★★
“I sleep well, wake up refreshed, and have more energy through the day.”
★★★★★
“My ability to think and organize has improved since I began taking it daily.”
Individual experiences may vary and are distinct from results observed in controlled clinical research.
A focus supplement only addresses today.
Core was designed for today + tomorrow.
Many focus products
- One immediate goal
- Often caffeine- or stimulant-centered
- Usually one or a few actives
- Typically no finished-formula clinical trial
NOVOS Core
- Calm-focus ingredients
- No caffeine
- Stress-adaptation ingredients
- Recovery-support ingredients
- 12-ingredient healthy-aging system
- Finished formula evaluated in a randomized human clinical trial (cardiovascular endpoints)
One minute for the next 24 hours, and the years ahead.
Mix one drink pack into water once a day. Most customers take Core in the morning, although some prefer evening use. Consistency matters more than the time of day.
- Sugar Free
- Vegan
- Gluten Free
- No Caffeine
- Third-Party Tested
- No Proprietary Blend
- Every Dose Disclosed
Built by longevity scientists, not trend marketers.
Developed with guidance from scientists and physicians whose expertise spans aging biology, genomics, neurobiology, nutrition and clinical medicine.
Dr. George Church
Harvard Medical School · MIT
Dr. João Pedro de Magalhães
Aging biology · genomics
Dr. Pamela Maher
Salk Institute
Dr. Diogo Barardo
NOVOS Scientific Team
Dr. Oliver Medvedik
NOVOS Scientific Team
Dr. Michael Rosenbaum
NOVOS Scientific Team
Listing an advisor does not imply they personally formulated Core or endorse any specific claim on this page.
A calmer mind. A stronger foundation.
Make resilience part of your daily routine.
L-Theanine. Rhodiola. Magnesium. Glycine. Plus the rest of NOVOS Core's 12-ingredient longevity system, in one sachet a day.
NOVOS Core · Orange
30 daily drink packs
- No caffeine · no stimulant spike
- Every dose disclosed · no proprietary blends
- Third-party tested
- Free shipping on subscriptions
Flavor
Plan
per box · billed every 6 months · about $3.10/day
Start NOVOS CorePause, skip or cancel anytime · Free shipping on subscriptions
Not ready? Try all 3 flavors: Sample Pack, $15.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Questions, answered plainly.
Calm focus · Whole-body longevity
Stay sharp without living in overdrive.
Support calm focus, stress resilience, recovery and healthy aging with one daily 12-ingredient longevity formula.
From approximately $2.63/day on the annual plan · Free shipping · Pause or cancel anytime
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
NOVOS Core
From $2.63/day