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The Science
The Science Behind
NOVOS Core
What real longevity research looks like
"Longevity" is everywhere in health and wellness — yet most products have never been studied for their effect on aging biology.
NOVOS Core is the exception. It has been evaluated in a randomized, double-blind, placebo-controlled clinical trial, preclinical lifespan studies, biological pace-of-aging research, and mechanistic studies.
Learn about the NOVOS Core clinical trial that set a new benchmark for human longevity
Randomized human clinical trial
NOVOS Core is one of the only longevity supplements ever evaluated in a randomized, double-blind, placebo-controlled clinical trial measuring biomarkers of cardiovascular aging.
Why this matters
Most supplement studies measure proxy biomarkers in blood tests. The NOVOS Core clinical trial instead measured direct physiological functions of the cardiovascular system — reflecting how well it is actually functioning, not just biochemical markers.
Measured endpoints:
Flow-mediated dilation
Measures endothelial function and blood vessel circulation capacity, which declines with age. NOVOS Core improved FMD by 2.9%. 1% is considered clinically meaningful.*
Pulse wave velocity
Measures the flexibility of blood vessels, which declines with age. NOVOS Core improved PWV by –1.18 m/s. Epidemiological studies find PWV increases by ~+1 m/s per decade of aging.*
Systolic blood pressure
Measures blood pressure, which increases with age. NOVOS Core improved blood pressure already within the normal range by 6.1 mmHg. 2-3 mmHg improvements in SBP are considered clinically meaningful.*
Improvements in endothelial function were observed both immediately after the first dose (1 hour) and sustained after six months of supplementation, suggesting NOVOS Core has both immediate and long-term biological effects.
"Taken together, improvements across endothelial function, arterial flexibility, and systolic blood pressure point to a coherent pattern consistent with a favorable shift in vascular aging biology."
Professor of Cardiology, University of Surrey
*These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
Primary Endpoint
FMD: The study's primary endpoint
Flow-mediated dilation (FMD) measures the ability of blood vessels to expand in response to increased blood flow — a key indicator of endothelial health and vascular function.
NOVOS Core significantly improved FMD both acutely (within 1 hour) and after 6 months of daily use, while the placebo group showed no meaningful change.
* p < 0.001 vs. placebo (statistical significance)
Baseline Age Equivalence
40–60+
years
FMD levels typically observed in
mid-to-late adulthood
NOVOS Age Equivalence
(1 hour and 6 months)
20–30+
years
Levels typically observed in
younger adult populations
Age-equivalent ranges are descriptive comparisons based on published reference values for flow-mediated dilation (FMD) in healthy populations (Holder et al., 2021; Maruhashi et al., 2020). Values may vary by methodology and individual characteristics. Acute and longer-term measurements reflect different physiological states.
This study did not assess clinical outcomes. These results do not imply diagnosis, treatment, cure, prevention of disease, or reduction in disease risk.
Data from a double-blind, randomized, placebo-controlled clinical trial in healthy adults aged 40+. Error bars represent 95% confidence intervals.
Why cardiovascular aging matters
Cardiovascular aging is one of the most important biological drivers of lifespan and healthspan.
Declines in endothelial function, decreased arterial flexibility, and rising blood pressure are strongly associated with aging and long-term health outcomes.
Improving these systems is therefore considered a key target in longevity research.
Comparison with published interventions
NOVOS Core clinical trial results vs. established health interventions*
The magnitude of improvement observed in the NOVOS Core clinical trial ranks among the strongest ever reported for a nutritional intervention targeting cardiovascular aging.
And dozens of other lifestyle interventions and supplements that the NOVOS Core study outperformed.
Importantly, these improvements were observed in healthy adults already within normal ranges, where further improvements are typically more difficult to achieve.
References:
Edwards et al. Br J Sports Med. 2023. pubmed.ncbi.nlm.nih.gov/37491419
Bakali et al. Open Heart. 2023. pubmed.ncbi.nlm.nih.gov/38101857
Davis et al. Am J Clin Nutr. 2017. pubmed.ncbi.nlm.nih.gov/28424187
Sansone et al. Br J Nutr. 2015. pubmed.ncbi.nlm.nih.gov/26348767
Lee et al. Curr Atheroscler Rep. 2023. pubmed.ncbi.nlm.nih.gov/37552456
Sabbatinelli et al. Nutrients. 2020. pubmed.ncbi.nlm.nih.gov/32326664
Behers et al. Nutrients. 2024. pubmed.ncbi.nlm.nih.gov/39519450
Celik et al. Nutr Rev. 2026. pubmed.ncbi.nlm.nih.gov/40679494
Cutler et al. Ann Epidemiol. 1991. pubmed.ncbi.nlm.nih.gov/1669517
*These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
The problem with most "science-based" supplements
Many supplement brands describe themselves as "science-backed."
In reality, that usually means something very different.
Cherry-picked studies
Citing research on individual ingredients — not their actual formula
Scientific theater
Hiring a spokesperson and using clinical-sounding language
Influencer claims
Personal routines positioned as scientific evidence
Extremely few study the actual formula they sell — yet biological interactions between ingredients can produce very different outcomes.
What happens when ingredients are combined?
Additive
1 + 1 = 2
Synergistic
1 + 1 = 3
Antagonistic
1 + 1 = –0.5
Biological interactions between compounds can produce very different outcomes.
Why combination formulas must be tested
A large study in Switzerland tested many combinations of longevity ingredients and measured their effects on animal lifespan. The results were surprising.
Most combinations did not outperform the best individual compound.
Some combinations improved outcomes. Others had no effect.
And some reduced lifespan.
Results of longevity compound combinations
of combinations performed equal to or worse than the best single ingredient.
of combinations reduced lifespan.
Synergy cannot be assumed.
It must be tested.
Most supplement companies never test their combinations. NOVOS did.
Phelps, Grace B, et al. "Comprehensive Evaluation of Lifespan-Extending Molecules in C. Elegans." Aging Cell, 24 Jan. 2025, https://doi.org/10.1111/acel.14424.
The NOVOS philosophy: measure the stack
NOVOS Core contains 12 ingredients designed to influence biological processes associated with aging. This approach is known as rational polypharmacy.
But instead of assuming synergy, NOVOS researchers chose to test the full formulation.
The resulting NOVOS research program spans
This is biotech-level research applied to natural supplements — extraordinarily rare in the industry.
NOVOS is the only consumer brand accepted into the Longevity Biotechnology Association, Healthy Longevity Medicine Society, and is one of only two supplement brands accepted to compete in the $101M XPRIZE for Healthspan.
The NOVOS research journey
7+ years of R&D spanning cellular, animal lifespan, and human clinical research.
Formulation research
Two years of evaluating compounds, mechanisms, and safety profiles across longevity pathways.
Mechanistic and cellular studies
Laboratory research examining how the combined formulation influences aging biology at the cellular level.
Human epigenetic aging research
Evaluating the impact on biological pace of aging using the DunedinPACE epigenetic clock.
Mouse lifespan study
Animal research observing lifespan extension with the full formulation in aged mice.
Human randomized clinical trial
Double-blind, placebo-controlled trial measuring biomarkers of cardiovascular aging.
Formulation research
Two years of evaluating compounds, mechanisms, and safety profiles across longevity pathways.
Mechanistic and cellular studies
Laboratory research examining how the combined formulation influences aging biology at the cellular level.
Human epigenetic aging research
Evaluating the impact on biological pace of aging using the DunedinPACE epigenetic clock.
Mouse lifespan study
Animal research observing lifespan extension with the full formulation in aged mice.
Human randomized clinical trial
Double-blind, placebo-controlled trial measuring biomarkers of cardiovascular aging.
A closer look at the evidence
The clinical trial showed the results. These are the additional studies that deepen the picture.
From epigenetic clocks to animal lifespan models and mechanistic cell studies — each layer of evidence adds to the clinical findings.
Human biological aging research
Participants taking NOVOS Core with NOVOS Boost for six months were evaluated using the DunedinPACE epigenetic aging clock that measures rate of biological aging.
Epigenetic clocks are widely used research tools that estimate biological aging by analyzing DNA methylation patterns. While these observational results are exploratory and not diagnostic or predictive of individual outcomes, they provide additional real-world data on how NOVOS Core may support aging-related biology over time. *These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
Skin structural aging
Using an indentometer to measure skin firmness, researchers evaluated the impact of six months of NOVOS Core supplementation.
Result: Average skin firmness improvement: +0%
Indentometer testing provides quantifiable insight into structural skin properties over time. While preliminary, these results suggest that supporting foundational biological pathways may also help maintain skin firmness and resilience. *These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
Lifespan research
A study in aged mice observed a median lifespan extension of more than 0%.
This is among the largest percentage increases in aged mouse lifespan ever achieved from a nutritional supplement.
Lifespan studies in animals are a foundational step in aging science for assessing whole-body biological effects. While results in animal models do not necessarily predict human outcomes, these findings, alongside mechanistic and human clinical research, provide additional evidence of system-level biological activity in vivo. *These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
Mechanistic studies
Laboratory research examined how the combined formulation influences biological processes associated with aging.
Cellular senescence
Reduction in aged, non-dividing cells that can cause cellular inflammation
See the researchCellular protection
Protection of human skin cells from chemotherapy-induced DNA double strand breaks
See the researchOxytosis / ferroptosis
Reduced oxidative cell death pathways linked to neurological aging
See the researchLaboratory research only. These findings are from in vitro (cell-based) studies. Results from laboratory models may not reflect how the product performs in the human body. *These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
A fundamentally different approach
These results didn't happen by accident. They're the outcome of targeting aging at its roots.
Instead of chasing single pathways, NOVOS Core was designed to address the 12 fundamental hallmarks of aging — the biological mechanisms that drive every aspect of how we age.
NOVOS Core: The First to Target The
12 Hallmarks of Aging
Aging is driven by multiple interacting biological processes.
Interventions targeting a single pathway may therefore have limited impact on whole-body aging biology.
NOVOS Core was designed to influence 12 aging pathways simultaneously through a carefully designed combination of ingredients.
Tap any hallmark to learn more
How NOVOS Core targets aging biology
Tap an ingredient to see which hallmarks of aging it targets
Genomic instability
3 ingredients
Telomere attrition
3 ingredients
Epigenetic alterations
6 ingredients
Loss of proteostasis
5 ingredients
Deregulated nutrient sensing
7 ingredients
Mitochondrial dysfunction
7 ingredients
Cellular senescence
1 ingredient
Stem cell exhaustion
2 ingredients
Altered intercellular communication
3 ingredients
Inflammaging
10 ingredients
Microbiome dysbiosis
5 ingredients
Impaired autophagy
6 ingredients
Built by longevity scientists
NOVOS was founded with a team of scientists and physicians from:
2 years
Evaluating compounds, pathways, and safety profiles before finalizing the formulation.
12 hallmarks
Designed to influence all hallmarks of aging simultaneously.
Patents
First patent for the NOVOS Core formulation filed in 2020.
Dr. George Church, PhD
Harvard Medical School & MIT Professor
"I see NOVOS as inspiring – they aim at all pathways and hallmarks of aging simultaneously."
Dr. Pamela Maher, PhD
University of British Columbia, Salk Institute for Biological Studies
“What really impressed me about NOVOS was the comprehensiveness of their analysis of aging research to design their product.”
Dr. J Pedro de Magalhaes, PhD
Harvard Medical School, University of Birmingham
“The NOVOS formulation is informed by science and is the current state-of-the-art in longevity supplements.”
Dr. Oliver Medvedik, PhD
Harvard Medical School, The Cooper Union
“NOVOS Core has been reviewed by scientists within the aging research community to ensure the most effective and safest ingredients.”
Dr. Avi Rosenbaum, PhD
Harvard Medical School
“NOVOS Core is among the most powerful longevity formulations available.”
Dr. Robert Lufkin, MD
USC School of Medicine
“It’s the rigorously-researched, science-backed formulations that set NOVOS apart in the longevity supplements space.”
What experts are saying
Recognized by clinicians and institutions
I was pleasantly surprised that the study showed both an acute improvement after the first dose and sustained improvement at six months. That kind of consistency is not common in supplement trials.
The magnitude of improvement observed in the study is notable compared with what is typically reported for nutritional interventions.
Recognized by clinicians and institutions
The scientific approach behind NOVOS has drawn attention from physicians and health institutions worldwide.
1,600+ MDs & clinicians share NOVOS Core
without compensation
"It has been a pleasure to watch NOVOS take a disciplined, biology-first approach, combined with a willingness to engage in rigorous evaluation rather than shortcuts, in a space that too often prioritizes hype over evidence."
DOINA KULICK, M.D.
LEAD PHYSICIAN, LONGEVITY MEDICINE PROGRAM AT MAYO CLINIC ARIZONA
NOVOS products are now available at world class hospitals and wellness retailers.
"NOVOS are pioneers in consumer longevity and among the first to develop a comprehensive approach that targets 12 mechanisms of aging simultaneously."
"A recent study places Novos Core as a leader among consumer antiaging interventions."
"A multi-ingredient longevity supplement made by the biotechnology company NOVOS may help improve markers of vascular aging."
The bottom line
What makes NOVOS Core different
Others cherry-pick.
Most supplement brands cite studies on individual ingredients — not their actual formula.
NOVOS tests.
7+ years of R&D — from cells to clinical trials on the real product.
Results speak.
Among the strongest results ever reported — in biological aging, cardiovascular function, and animal lifespan studies.
Experts agree.
1,600+ MDs & clinicians recommend NOVOS Core — without compensation.
The future of longevity science
This is only the beginning.
Ongoing research
Future studies will evaluate how NOVOS Core influences additional organ systems and aging biomarkers beyond cardiovascular function.
Advancing the field
By publishing openly and inviting scrutiny, NOVOS aims to raise the evidence standard for the entire longevity industry.
Longevity science is still evolving.
NOVOS is committed to evolving with it — through research, not assumptions.
12 ingredients. 12 hallmarks.
One daily sachet.
Each NOVOS Core sachet delivers a precise combination of longevity ingredients backed by peer-reviewed research and tested in a randomized clinical trial.
Learn More About NOVOS Core